Myotonic Dystrophy: Major Problems in Neurology: 37 Book

A specialist monograph in the highly acclaimed Major Problems in Neurology series. Myotonic Dystrophy is one of the most variable of all human disorders. With age onset ranging from fetal life to old age, and with virtually all systems of the body affected in some way, it can present clinically to many types of specialist; not only the neurologist but also the cardiologist, ophthalmologists, gastroenterologist or endocrinologist. This book is written for all who may encounter myotonic dystrophy in whatever way. The main part of this book examines the various aspects of myotonic dystrophy in the light of current knowledge. Thus the neurological features and differential diagnosis are covered in details, as are the muscular, cardiovascular, and other aspects of the disease. Muscle pathology and neurophysiology are also described fully. Much new material is contained within the chapters on genetics, in particular the new research and understanding of the primmary molecular defect in this disorder, the concept of unstable DNA, and the existence of trinucleotide repeats. This information is invaluable to both clinicians and researchers working in the field. Finally, clinical management is descibed so that all cliniciansinvolved with myotonic dystrophy, whatever their specialty, can find practical guidance on how to improve their patients' condition. Read More