Nicotine Safety and Toxicity Book

Nicotine has been developed as a medication ta assist smoking cessation, and is being considered as a possible drug for the long-term management of non-smoking. It is also being evaluated as treatment for severalk medical disorders, including ulcerative colitis, Alzheimer's disease, Parkinson's disease, Tourette's syndrome, attention deficit disorder, spastisity, ans sleep apnea. Understanding its safety and toxitity is essential for drug developers, drug regulators, and clinicians making risk/benefit decisions about long-term nicotine therapy. Research on nicotine toxicity is also relevant to research on tobacco and health aimed at understanding the role of nicotine in contrbuting to tobacco-induced disease. This book reviews the current scientific understanding of the safety and toxicity of nicotine. The discussion ranges from chemistry, through animal and human experimental research, to the results of large clinical trials. Among the topics covered are cardiovascular disease, cancer, reproductive toxicity (including fetal toxicity and Sudden Infant Death Syndrome), behavioral toxicity (including abuse liability and addiction to nicotine medication) and gastrointestinal disease. Finally, the risks and benefits of nicotine as a medication are explored. The authors are world-renowned experts on their respective topics. No other book addresses nicotine toxicity with the depth or breadth of this volume.Read More