The Organic Chemistry of Enzyme-catalyzed Reactions Book

Written for advanced undergraduate and graduate students as well as professionals in organicand medicinal chemistry and biochemistry, this unique text illuminates the "black box" ofenzyme-catalyzed reactions by showing how enzymes are simply highly efficient organicchemists. Enzyme-catalyzed reactions are essential for the design of enzyme inhibitors in thepharmaceutical and agricultural industries, and of growing importance for process developmentin the chemical and biotechnology industries. Following a general introduction to the role ofenzymes as catalysts, each chapter describes the organic reaction mechanisms that are used byenzymes to catalyze a particular family of organic transformations. The compilation includes avast number of drawings to illustrate structures and mechanisms, and focuses on one or twoexamples of enzymes that catalyze the particular chemistry for that transformation. The OrganicChemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather the generalmechanisms used by enzymes. Extensive references refer to the many experiments that havehelped to elucidate enzyme mechanisms. Chemical model studies as an aid in mechanisticstudies are also discussed, as are the design of haptens and the generation of catalytic antibodies("designer enzymes"). Problem sets and solutions are provided to check the reader's understanding of the principles described. * Shows how enzyme-catalyzed reactions are simplyefficient organic reaction* Emphasizes the connection between organic reaction mechanisms and enzyme mechanisms* Explains how enzymes can accelerate the rates of chemical reactions with high specificity* Uses selected enzymes to demonstrate general mechanisms of enzyme-catalyzed reaction* Illustrated with a vast array of clearly drawn structures, schemes, and figures* Includes an extensive bibliography on enzyme mechanisms * Describes approaches to the design of enzyme inhibitors* Covers catalytic antibody design and mechanisms* Provides problem sets and solutions for each chapter* Written in an informal and engaging styleRead More